I have been getting very confused between the mouse wheel scroll directions in Windows 7 and Mac OS X Lion. As I consider OS X to be the future, I decided to try and flip the mouse wheel scroll direction in Windows.
Turns out there is a registry setting to do this:
Set the value of FlipFlopWheel to 1
You need to find the USB enumeration values (shown above as ????). You can get those by going to the Mouse Control Panel, click on the hardware tab and click Properties. then in the Details tab of the HID-compliant mouse Properties window, look at the Device Instance Path property. It will be something like:
This is quite well documented on superuser.com and there is even a link to a little .exe that automates the whole process for you. Although I have not tried it so I can’t vouch for it.